Fructose exits the enterocyte on the basolateral membrane via which transporter?

Fructose exits the enterocyte on the basolateral membrane via which transporter?

• A. GLUT5
• B. GLUT2
• C. SGLT1
• D. GLUT1

Answer: (B)

Fructose moves from the gut lumen into the enterocyte via GLUT5 on the apical (brush border) surface, then exits into the bloodstream through GLUT2 on the basolateral membrane. GLUT2 is the main basolateral hexose transporter in enterocytes, capable of carrying fructose, glucose, and galactose into the portal blood. SGLT1 handles the apical uptake of glucose (sodium-dependent), and GLUT1 is a general, non–enterocyte-specific transporter, not the key route for basolateral exit. Thus, the basolateral exit pathway for fructose is through GLUT2.

Fructose moves from the gut lumen into the enterocyte via GLUT5 on the apical (brush border) surface, then exits into the bloodstream through GLUT2 on the basolateral membrane. GLUT2 is the main basolateral hexose transporter in enterocytes, capable of carrying fructose, glucose, and galactose into the portal blood. SGLT1 handles the apical uptake of glucose (sodium-dependent), and GLUT1 is a general, non–enterocyte-specific transporter, not the key route for basolateral exit. Thus, the basolateral exit pathway for fructose is through GLUT2.