Which basolateral transporter is used for fructose exit from enterocytes?

Which basolateral transporter is used for fructose exit from enterocytes?

• A. GLUT2
• B. GLUT5
• C. SGLT1
• D. GLUT1

Answer: (A)

Movement of sugars across enterocytes uses distinct transporters on the two surfaces. Fructose enters the cell from the gut lumen via GLUT5 on the apical membrane, then leaves the cell into the bloodstream through GLUT2 on the basolateral membrane. GLUT2 handles fructose (as well as glucose and galactose) for exit into blood, making it the key basolateral transporter for fructose. The other transporters have different roles: SGLT1 brings glucose into the cell from the lumen, GLUT1 is a more general basolateral/others transporter, and GLUT5 is specific to fructose uptake at the apical side, not the exit.

Movement of sugars across enterocytes uses distinct transporters on the two surfaces. Fructose enters the cell from the gut lumen via GLUT5 on the apical membrane, then leaves the cell into the bloodstream through GLUT2 on the basolateral membrane. GLUT2 handles fructose (as well as glucose and galactose) for exit into blood, making it the key basolateral transporter for fructose. The other transporters have different roles: SGLT1 brings glucose into the cell from the lumen, GLUT1 is a more general basolateral/others transporter, and GLUT5 is specific to fructose uptake at the apical side, not the exit.